Combined inhibition of MDM2 and PARP lead to a synergistic anti-tumoral response in p53 wild-type rhabdomyosarcoma models
Guillem Pons, Patricia Zarzosa, Gabriel Gallo-Oller, Amelie S. Wenz, Maris Lapins, Lia García-Gilabert, Júlia Sansa-Girona, Natalia Navarro, Miguel F. Segura, Aroa Soriano, Gabriela Guillén, Raquel Hladun, Josep Sánchez de Toledo, Soledad Gallego, Jordi Carreras Puigvert, , Josep M Roma
This study shows that combining MDM2 and PARP inhibitors synergistically inhibits p53 wild-type rhabdomyosarcoma growth in vitro and in vivo.
bioRxiv · Dec 3, 2024 · PreprintCancer Biology