Author

Maris Lapins

Uppsala UniversityORCID 0000-0002-0122-6680Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:imaging· 1 Approach:machine learning (classical)· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

Jordi Carreras PuigvertiD· 2 shared Ola SpjuthiD· 2 shared Adelinn KalmaniD· 1 shared Alicia Soler· 1 shared Amelie S. WenziD· 1 shared Andrea ZalianiiD· 1 shared Aroa SorianoiD· 1 shared Brinton A. Seashore-LudlowiD· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersMicrobiology

Jordi Carreras PuigvertORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Morphological cell profiling for drug repurposing against SARS-CoV-2 infection

Elin Asp, Jonne Rietdijk, Marianna Tampere, Hanna Axelsson, Duncan T. Njenda, Swapnil Potdar, Adelinn Kalman, Polina Georgieva, Maris Lapins, Flavio Ballante, Alicia Soler, Martin de Kort, Tero A. Aittokallio, Andrea Zaliani, Maria Kuzikov, , Päivi Östling

The paper identifies host-targeting antivirals against SARS-CoV-2 using morphological profiling, finding compounds that reverse infected cell phenotypes and validate host processes hijacked by viruses.

bioRxiv · Aug 28, 2025 · PreprintMicrobiology

Combined inhibition of MDM2 and PARP lead to a synergistic anti-tumoral response in p53 wild-type rhabdomyosarcoma models

Guillem Pons, Patricia Zarzosa, Gabriel Gallo-Oller, Amelie S. Wenz, Maris Lapins, Lia García-Gilabert, Júlia Sansa-Girona, Natalia Navarro, Miguel F. Segura, Aroa Soriano, Gabriela Guillén, Raquel Hladun, Josep Sánchez de Toledo, Soledad Gallego, Jordi Carreras Puigvert, , Josep M Roma

This study shows that combining MDM2 and PARP inhibitors synergistically inhibits p53 wild-type rhabdomyosarcoma growth in vitro and in vivo.

bioRxiv · Dec 3, 2024 · PreprintCancer Biology

Evaluation of gene expression and phenotypic profiling data as quantitative descriptors for predicting drug targets and mechanisms of action

Maris Lapins, Ola Spjuth

This study evaluates machine learning models using gene expression and phenotypic profiling data to predict drug mechanisms of action and targets, showing varying accuracy across endpoints and the potential benefit of combining methods.

bioRxiv · Jul 3, 2019 · PreprintBioinformatics