Integrated single-cell transcriptomics and epigenomics reveals strong germinal center-associated etiology of autoimmune risk loci
Hamish W. King, Kristen L. Wells, Zohar Shipony, Arwa S. Kathiria, Lisa E. Wagar, Caleb A. Lareau, Nara T. Orban, Robson Capasso, Mark M. Davis, Lars Michael Steinmetz, Louisa Katherine James, William James Greenleaf
The paper uses single-cell transcriptomics and epigenomics to analyze immune cell subsets in human tonsils, revealing that autoimmune risk variants have strong regulatory potential in germinal center cells.
Science Immunology · Oct 13, 2021Peer-reviewedGenomics