Louisa Katherine James

Characterisation of Peripheral Blood B Cell Receptor Repertoire in Severe Eosinophilic Asthma and EGPA

This study characterizes B cell receptor repertoires in severe eosinophilic asthma and EGPA, finding increased IgG4 and other subclasses, shared clones, and treatment-related changes.

Single cell sequencing data identify distinct B cell and fibroblast populations in stricturing Crohns disease

The paper uses single-cell RNA sequencing to identify distinct B cell and fibroblast populations in stricturing Crohn's disease, highlighting their potential roles in fibrosis.

Cell2location maps fine-grained cell types in spatial transcriptomics

cell2location uses a Bayesian model to integrate single-cell and spatial transcriptomics, mapping cell types in situ across mouse brain regions and human lymph node immune compartments.

Integrated single-cell transcriptomics and epigenomics reveals strong germinal center-associated etiology of autoimmune risk loci

The paper uses single-cell transcriptomics and epigenomics to analyze immune cell subsets in human tonsils, revealing that autoimmune risk variants have strong regulatory potential in germinal center cells.