Lisa E. Wagar

The paper classifies human Th17 cells into non-pathogenic and pathogenic states and identifies acylcarnitine metabolism as a vulnerability in type 2 diabetes.

This study develops an EBV-infected tonsil organoid model to study B cell states and antiviral responses during primary infection, revealing unique transcriptional programs and immune interactions.

This study develops a lymphoid-tissue-on-chip model that recapitulates human antibody responses to influenza vaccines in vitro.

This study shows that malaria exposure increases cytotoxic Vδ2+ T cell expansion in human tonsil and spleen organoids, with clonal expansion and activation, while not significantly affecting influenza vaccine responses.

This study examines age-related differences in T follicular helper cell function and their impact on antibody responses across human development.

This study analyzes T cell receptor repertoires in blood and tonsils, finding low clonal sharing and tissue-specific diversity, emphasizing the need for tissue-based analysis.

The paper uses single-cell transcriptomics and epigenomics to analyze immune cell subsets in human tonsils, revealing that autoimmune risk variants have strong regulatory potential in germinal center cells.

This study identifies novel MHC-I antigens specific to dengue virus infection using an immuno-proteomics approach, revealing ligands associated with distinct HLA haplotypes and T-cell recognition.