Hamish W. King

This study shows that ambient RNA correction can reduce doublet detection accuracy and recommends detecting doublets before correction, except when using CellBender.

This study identifies distinct cellular and microbial profiles in PSC-UC and UC patients using single-cell and spatial transcriptomics, revealing shared and unique inflammatory mechanisms.

Single-cell RNA and BCR sequencing of infected mouse spleens shows class switching overlaps clonal expansion, GC-seeding clones also form plasmablasts, and SHM proceeds at constant rate.

This study uses single-cell multi-omics to compare immune cell landscapes and vaccine responses in SAD and CVID patients, identifying unique cellular and molecular features associated with poor vaccination responses.

SpatialBench evaluates spatial transcriptomics platforms using a mouse spleen model, finding consistent biological signals but varying resolution across technologies.

The paper uses single-cell CRISPR activation screens in human B cells to link non-coding autoimmune risk loci to their cis-regulatory target genes, revealing shared genetic mechanisms across diseases.

This study identifies ZFP36L1 and ZFP36L2 as RNA-binding proteins that regulate the G2-M checkpoint in GC B cells to prevent replication stress and maintain genome stability.

cell2location uses a Bayesian model to integrate single-cell and spatial transcriptomics, mapping cell types in situ across mouse brain regions and human lymph node immune compartments.

The paper uses single-cell transcriptomics and epigenomics to analyze immune cell subsets in human tonsils, revealing that autoimmune risk variants have strong regulatory potential in germinal center cells.

This study uses single-cell RNA-sequencing to analyze fetal bone marrow development and identifies disruptions in hematopoiesis in Down syndrome.

This study shows KDM2 proteins repress transcription from CpG island promoters without relying on their histone demethylase activity.

The paper investigates how DNA methylation and histone acetylation independently affect transcription factor binding and gene expression in mouse embryonic stem cells.

The paper investigates the role of PcG proteins in chromatin accessibility and nucleosome organization in mouse embryonic stem cells, finding that PcG proteins do not significantly affect chromatin accessibility but influence nucleosome occupancy and spacing.