Luca Schulz

Designing enzymes for new-to-nature chemistry and non-natural substrates with AlphaProtein Novo

This paper introduces AlphaProtein Novo, a machine-learning pipeline for de novo enzyme design that outperforms natural sequence mining in creating enzymes for new-to-nature chemistry and substrates.

Microcystin-Driven Control of the Carbon-Concentrating Mechanism Shapes CO2 Fixation Dynamics in Microcystis aeruginosa PCC 7806

This study shows that microcystin (MC) in Microcystis aeruginosa enhances carbon fixation by activating the carbon-concentrating mechanism (CCM) and altering photosynthetic processes under fluctuating light conditions.

Form IF Rubiscos include highly active, specific, and small subunit-independent enzymes.

The paper identifies Form IF Rubiscos that are highly active, specific, and function without the small subunit, challenging the necessity of subunit complexity in Rubisco evolution.

Origin of chaperone dependence and assembly complexity in Rubisco biogenesis

The paper investigates the evolutionary origin of chaperone dependence in Rubisco biogenesis and finds that this dependence evolved neutrally and can be reversed without affecting catalytic function.

Cell-free prototyping enables implementation of optimized reverse beta-oxidation pathways in heterotrophic and autotrophic bacteria

The paper optimizes and implements reverse beta-oxidation pathways in bacteria for carbon-negative synthesis of C4-C6 acids and alcohols, achieving high product titers in engineered strains.