Thierry Touzé

Polysaccharide release factors drive lipid-carrier recycling in bacteria

The paper identifies three periplasmic enzymes in E. coli that release polysaccharide cargo from the lipid carrier undecaprenyl, revealing a mechanism for bacterial envelope biogenesis and potential antibiotic targets.

Mechanistic insights into Enterocin C targeting the undecaprenyl phosphate recycling protein BacA

This study identifies Enterocin C's mechanism of action by targeting BacA, revealing cooperative peptide interactions leading to cell death and suggesting potential for bioengineering antimicrobials.