Guido T. Bommer

The paper identifies three periplasmic enzymes in E. coli that release polysaccharide cargo from the lipid carrier undecaprenyl, revealing a mechanism for bacterial envelope biogenesis and potential antibiotic targets.

This study identifies two yeast enzymes, Env9 and Tda5, that perform distinct steps in dolichol biosynthesis, replacing the dual role of DHRSX in humans.

The paper investigates the role of LACTB in Alzheimer's disease risk through Mendelian Randomization and experimental models, finding reduced LACTB expression lowers AD risk and increases succinylcarnitine levels.

The paper investigates how mitochondrial DNA variants affect telomere length using transmitochondrial cybrids, finding an inverse correlation between donor telomere length and mitochondrial ROS levels.

This study shows that LDHA is essential for maintaining NAD+/NADH balance in AML cells, and its inhibition leads to cell death, suggesting it as a therapeutic target.

The paper identifies LyLAP as a key enzyme for lysosomal degradation of transmembrane proteins, showing its role in maintaining endocytic activity and lysosomal stability in pancreatic cancer.

This study identifies DHRSX gene absence as the cause of dolichol synthesis defect in Lec5 and Lec9 CHO cells, correcting N-glycosylation defects through DHRSX complementation.