Calcitonin-Driven Reactivation of the Hippo Tumor-Suppressor Cascade Attenuates YAP/TAZ Oncogenic Signaling in Glioblastoma
Jayita Goswami, Prithviraj Uttarasili, Lakshay Garg, Kaval Reddy Prasasvi, Abhishek Chowdhury, Subhrodeep Saha, Jayanta Chatterjee, Anand Kumar Srivastava, Kumaravel Somasundaram
This study shows that calcitonin activates the Hippo pathway via CTR to inhibit YAP/TAZ in glioblastoma, with structural defects in CTR mutants impairing this effect.
bioRxiv · Nov 20, 2025 · PreprintCancer Biology