Kumaravel Somasundaram

This study identifies SEZ6 as a glioma stem cell-specific proangiogenic molecule that promotes angiogenesis through TGFβ signaling, offering a novel therapeutic target for glioblastoma.

This study shows PARP16 reduces cardiac remodelling by inhibiting NFAT transcription through ADP-ribosylation, with implications for heart failure treatment.

This study shows PARP1 deficiency causes aging-related cardiac failure by activating Akt signaling, leading to hypertrophy and fibrosis in mice.

This study shows that calcitonin activates the Hippo pathway via CTR to inhibit YAP/TAZ in glioblastoma, with structural defects in CTR mutants impairing this effect.

This study shows that m6A reader proteins IGF2BP2 and HNRNPA2B1 differentially regulate H19 lncRNA processing, with IGF2BP2 enhancing stability and HNRNPA2B1 promoting miR-675 biogenesis, which drives glioma cell migration.

This study identifies BAZ1A as a key component of an ISWI complex that recruits E2F1 to activate the E2F transcription program, promoting G1-S progression in glioma cells.

This study analyzes SARS-CoV-2 genetic diversity in Indian isolates, identifying two main clades with origins linked to Oceania, Europe, Middle East, and South Asia, suggesting transmission routes through highly traveled regions.