Targeting Estrogen to the Brain via the Prodrug DHED does not Protect Against Metabolic Dysfunction in Obese, OVX mice.
Celine Camon, Elodie Kip, Rebecca A Lord, Caroline Decourt, Mel Prescott, Jenny Clarkson, Katalin Prókai-Tátrai, Stephanie M. Correa, Rebecca E. Campbell, Michael Garratt
This study tests if brain-targeted estrogen via DHED prodrug improves metabolic health in obese, ovariectomized mice, but finds no such benefit.
bioRxiv · Jan 28, 2026 · PreprintPhysiology