Michael Garratt

This study tests if brain-targeted estrogen via DHED prodrug improves metabolic health in obese, ovariectomized mice, but finds no such benefit.

This study develops an epigenetic clock for sheep and finds that castration slows aging and feminizes DNA methylation at androgen-regulated loci.

This study shows 17a-Estradiol reduces neuroinflammation in male mice but not females, with effects mediated by gonadal hormones and region-specific brain changes.