Chronic opioid treatment arrests neurodevelopment and alters synaptic activity in human midbrain organoids
Hye Sung Kim, Yang Xiao, Xuejing Chen, Siyu He, Jongwon Im, Moshe J. Willner, Michael O. Finlayson, Cong Xu, Huixiang Zhu, Se Joon Choi, Eugene V. Mosharov, Hae‐Won Kim, Bin Xu, Kam W. Leong
This study examines the effects of chronic and acute fentanyl exposure on midbrain organoids, finding that chronic treatment arrests neuronal development and alters synaptic pathways.
Advanced Science · Mar 28, 2024Peer-reviewedNeuroscience