Se Joon Choi

This study presents cryo-EM structures of SV2C and its ligands, revealing structural differences that explain ligand selectivity and impact dopamine release.

This study identifies a mechanism by which α-synuclein and γ-tubulin cooperatively regulate activity-evoked presynaptic microtubule nucleation to control dopamine release.

This study shows that electroconvulsive therapy (ECT) improves motor function in Parkinsonian mice by promoting dopaminergic axon regeneration and restoring striatal circuitry.

The paper shows that sound-safety association enhances striatal neuron responses to learned sounds through postsynaptic changes in direct pathway SPNs.

This study improves the yield and subtype identity of hPSC-derived midbrain dopamine neurons through optimized WNT and FGF18 signaling modulation, enhancing their functional and transcriptional similarity to primary neurons.

This study examines the effects of chronic and acute fentanyl exposure on midbrain organoids, finding that chronic treatment arrests neuronal development and alters synaptic pathways.

The paper uses subcellular proteomics to show Parkinson's disease-linked genes are enriched in axons of dopaminergic neurons in the mouse brain.

This study investigates how dopamine loss and chronic L-DOPA treatment affect striatal cholinergic interneuron firing rates and ion channel activity, revealing specific molecular adaptations.

This study shows that the lipid environment affects dopamine transporter function, specifically influencing amphetamine response in mice.