Eugene V. Mosharov

This study develops a method to derive and maintain specific subtypes of human midbrain dopaminergic neurons in vitro, revealing their functional and molecular characteristics and potential vulnerability in disease.

This study presents cryo-EM structures of SV2C and its ligands, revealing structural differences that explain ligand selectivity and impact dopamine release.

This study examines how ADGRL3 knockout affects dopamine release in mice, finding increased ex vivo release and reduced in vivo task-induced signals in the nucleus accumbens.

This paper introduces a neuroimaging framework to map brain mitochondria non-invasively and finds age-related declines in mitochondrial density and respiratory capacity, along with disease-specific alterations and links to systemic stress and cognition.

This study identifies a mechanism by which α-synuclein and γ-tubulin cooperatively regulate activity-evoked presynaptic microtubule nucleation to control dopamine release.

This study shows α-synuclein modulates spontaneous dopamine release via calcium and phosphorylation-dependent mechanisms, independent of full-fusion recycling.

This study shows that electroconvulsive therapy (ECT) improves motor function in Parkinsonian mice by promoting dopaminergic axon regeneration and restoring striatal circuitry.

The paper shows that sound-safety association enhances striatal neuron responses to learned sounds through postsynaptic changes in direct pathway SPNs.

The paper creates a brain-wide map of mitochondrial phenotypes by combining physical voxelization with biochemical profiling, revealing regional differences in mitochondrial density and function.

The paper investigates how tonic activity patterns affect dopamine release in striatal brain slices, finding that tonic stimulation alters DA release kinetics to resemble in vivo conditions.

This study improves the yield and subtype identity of hPSC-derived midbrain dopamine neurons through optimized WNT and FGF18 signaling modulation, enhancing their functional and transcriptional similarity to primary neurons.

This study investigates dopamine neurotransmission in an eIF4E Tg mouse model of ASD, finding impaired striatal dopamine release and behavioral inflexibility due to defective nicotinic receptor signaling.

This study examines the effects of chronic and acute fentanyl exposure on midbrain organoids, finding that chronic treatment arrests neuronal development and alters synaptic pathways.

The paper shows IFN-γ induces MHC-I expression in ventral midbrain neurons and glia, but with lower amplitude in neurons, and MHC-II is restricted to microglia.

The paper presents three computational models to analyze fast-scan cyclic voltammetry data from mice, quantifying presynaptic dopamine kinetics and the role of synucleins in neurotransmission.

The paper investigates mRNA localization and translation in midbrain dopaminergic neurons, finding no axonal localization but dendritic ribosomes and mRNAs related to dopamine synthesis and release.

The paper examines mitochondrial respiratory chain capacity and its association with stress-related behaviors in mice, identifying brain networks linked to anxiety-like behavior.

This study investigates how dopamine loss and chronic L-DOPA treatment affect striatal cholinergic interneuron firing rates and ion channel activity, revealing specific molecular adaptations.

This study shows α-synuclein enhances dopamine release during burst firing in substantia nigra neurons in vivo, independent of β- and γ-synucleins or presynaptic calcium.

This study shows that the lipid environment affects dopamine transporter function, specifically influencing amphetamine response in mice.

The paper investigates how stress-induced phospho-ubiquitin formation leads to parkin degradation through oxidative and non-oxidative pathways, potentially contributing to Parkinson's disease.

This study shows psychological stress increases circulating cell-free mitochondrial DNA (ccf-mtDNA) in humans through glucocorticoid signaling, with no change in nuclear DNA levels.