Walid D. Fakhouri

TWIST1 Modulates Cilia Length, Endocytic Vesicle Dynamics, and Cell-Cell Junctions during Neural Tube Morphogenesis

The paper investigates TWIST1's role in neural tube morphogenesis by examining its effects on cilia length, endocytic vesicle dynamics, and cell-cell junctions in mutant embryos.

Sequence-to-expression approach to identify etiological non-coding DNA variations in P53 and cMYC-driven diseases

The paper identifies non-coding DNA variations affecting P53 and cMYC-driven diseases by analyzing co-occupancy of these transcription factors and correlating DNA variations with gene expression changes.

High incidence and geographic distribution of cleft palate cases in Finland are associated with a regulatory variant in IRF6

The paper identifies a regulatory variant in IRF6 associated with increased cleft palate risk in Finland and shows it disrupts IRF6 enhancer function.

TWIST1 interacts with adherens junction proteins during neural tube formation and regulates fate transition in cranial neural crest cells

This study identifies a new role for Twist1 in neural tube development and epithelial-to-mesenchymal transition in cranial neural crest cells, showing its interaction with Irf6 and impact on cytoskeletal remodeling and facial morphology.

Unbiased association and expression studies identify novel genes for tooth development

The paper identifies novel genes for tooth development by associating CRC risk variants with tooth agenesis and showing gene expression in developing teeth.