Sally Lowell

The paper identifies two thresholds of Brachyury expression in NMPs that determine lineage potential and axis-forming ability in vitro.

The paper introduces a toolkit to analyze cell identity patterning by comparing cells to their neighbors, revealing Notch-dependent heterogeneity in neuromesodermal progenitors.

PUFFFIN labels cell neighbourhoods using a fluorescent protein fusion, enabling tracking of cell interactions and profiling non-cell-autonomous responses in mammalian cells.

This study compares phenotypes of Pax6 mutant cerebral organoids with Pax6 mutant mouse embryos, finding similarities in neural differentiation and cell cycle changes.

SyNPL uses Synthetic Notch technology to monitor and manipulate cell-cell interactions in pluripotent stem cells and embryos, enabling synthetic patterning of cell fates.

This study identifies a new role for Twist1 in neural tube development and epithelial-to-mesenchymal transition in cranial neural crest cells, showing its interaction with Irf6 and impact on cytoskeletal remodeling and facial morphology.

This study shows that E2A drives neural differentiation in pluripotent mouse cells by activating neural lineage genes and repressing Nodal signalling.

This study shows that competence to epithelialise and differentiate in pluripotent cells is regulated by Tcf15, linking these processes through integrin alpha3 upregulation.

Nessys provides a method for accurate 3D nuclear segmentation in dense, heterogeneous tissues and tracks cell interactions during differentiation.

This study shows N-cadherin stabilizes neural identity by reducing anti-neural signals during differentiation.

This study shows that geometric cues can direct the self-patterning of Brachyury-positive cells in embryonic stem cell aggregates without relying on morphogen gradients.