An J. Tran

This study shows that loss of SPECC1L in cranial neural crest cells causes increased Hedgehog signaling and craniofacial defects similar to human syndrome.

The paper shows that SPECC1L regulates F-actin levels, which in turn affects cilia length and palate development, with a genetic interaction with Thm1.

The paper investigates TWIST1's role in neural tube morphogenesis by examining its effects on cilia length, endocytic vesicle dynamics, and cell-cell junctions in mutant embryos.