Jianming Xu

STAG2 cohesin cooperates with DREAM to maintain quiescence and suppress tumourigenesis in the urothelium

This study shows that STAG2 cohesin works with DREAM to maintain quiescence and prevent tumor formation in urothelial cells by regulating chromatin structure and cell cycle control.

TWIST1 Modulates Cilia Length, Endocytic Vesicle Dynamics, and Cell-Cell Junctions during Neural Tube Morphogenesis

The paper investigates TWIST1's role in neural tube morphogenesis by examining its effects on cilia length, endocytic vesicle dynamics, and cell-cell junctions in mutant embryos.

Human myelocyte and metamyelocyte-stage neutrophils suppress tumor immunity and promote cancer progression

The paper identifies human myelocyte and metamyelocyte-stage neutrophils as immunosuppressive cells that promote cancer progression and suggests targeting them for immunotherapy.

Noncanonical Wnt/Ror2 Signaling Regulates Basal Cell Fidelity and Branching Morphogenesis in the Mammary Gland

This study shows that noncanonical Wnt signaling via Ror2 maintains basal cell identity in mammary glands, preventing fate transitions to luminal cells and ensuring proper branching morphogenesis.

Bi-compartmentalized stem cell organization of the corneal limbal niche

The paper uses live imaging to reveal distinct stem cell activities in the limbal niche during corneal regeneration.

Employing single-stranded DNA donors for the high-throughput production of conditional knockout alleles in mice

This study tests CRISPR/Cas9 with ssODNs and lssODNs for generating conditional knockout alleles in mice, finding higher efficiency with lssODNs.