Author

George Jing Xu

University of California San DiegoORCID 0000-0003-2129-5701Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Genetic & Genomic Medicine· 2

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:whole-exome sequencing· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Adam Stuart KibeliD· 2 shared Anders Martin DaleiD· 2 shared Anna M. DornischiD· 2 shared Anna PlymiD· 2 shared Azad Razack· 2 shared Barbara A. MurphyiD· 2 shared Barry S. RosensteiniD· 2 shared Brent Shane RoseiD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

Adam Stuart KibelORCID

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Author profile →

4 papers

Recent·Most cited

Germline polygenic score for prostate cancer aggressiveness

George Jing Xu, Roshan A. Karunamuni, Anna M. Dornisch, Charles A. Brunette, Morgan E. Danowski, Heena Desai, Daniel R. Dochtermann, Isla P. Garraway, Richard L. Hauger, Adam Stuart Kibel, Julie Ann Lynch, Saiju Pyarajan, Brent Shane Rose, Craig Carl Teerlink, Ole A. Andreassen, , Tyler M. Seibert

This paper develops a germline polygenic score (PRSagg) to predict prostate cancer aggressiveness and validates it across multiple datasets.

medRxiv · May 13, 2026 · PreprintGenetic & Genomic Medicine

An integrated single-cell and spatial transcriptomic atlas of thyroid cancer progression identifies prognostic fibroblast subpopulations

Matthew A. Loberg, George Jing Xu, Sheau‐Chiann Chen, Hua‐Chang Chen, Claudia C. Wahoski, Kailey P. Caroland, Megan L. Tigue, Heather A. Hartmann, Jean‐Nicolas Gallant, Courtney J. Phifer, Andres A. Ocampo, Dayle K. Wang, Reilly G. Fankhauser, Kirti A. Karunakaran, Chia-Chin Wu, , Vivian Lee Weiss

This study integrates single-cell and spatial transcriptomics to identify prognostic fibroblast subpopulations in thyroid cancer progression.

JCI Insight · Jan 1, 2026Peer-reviewedCancer Biology

Tenascin-C potentiates Wnt signaling in thyroid cancer

Heather A. Hartmann, Matthew A. Loberg, George Jing Xu, Anna Schwarzkopf, Sheau‐Chiann Chen, Courtney J. Phifer, Kailey P. Caroland, Hua-Chang Chen, Diana Diaz, Megan L. Tigue, Amanda B. Hesterberg, Jean‐Nicolas Gallant, Sophia M. Shaddy, Quanhu Sheng, James L. Netterville, , Vivian Lee Weiss

This study shows that Tenascin-C enhances Wnt signaling and promotes invasion and metastasis in thyroid cancer through in vitro and in vivo experiments.

Endocrinology · Feb 5, 2025Peer-reviewedCancer Biology

From a genomic risk model to clinical trial implementation in a learning health system: the ProGRESS Study

Jason L. Vassy, Anna M. Dornisch, Roshan A. Karunamuni, Michael Gatzen, C. Kachulis, Niall J. Lennon, Charles A. Brunette, Morgan E. Danowski, Richard L. Hauger, Isla P. Garraway, Adam Stuart Kibel, Kyung Min Lee, Julie Ann Lynch, Kara N. Maxwell, Brent Shane Rose, , Tyler M. Seibert

The paper develops a polygenic risk model for prostate cancer using VA data and validates it in external cohorts, showing its clinical utility in risk stratification.

medRxiv · Nov 3, 2024 · PreprintGenetic & Genomic Medicine