Michael P. Latham

How a highly acidic SH3 domain binds to its intrinsically disordered partner through the formation of an encounter complex intermediate

The paper investigates how the highly acidic SH3 domain binds to an intrinsically disordered partner through an encounter complex intermediate, revealing the role of long-range electrostatic interactions.

SPINDLE: Unlocking protein dynamics from single-field NMR relaxation data using a deep learning ensemble.

SPINDLE uses deep learning to predict protein dynamics from single-field NMR data, outperforming traditional methods and reproducing experimental results for 50 proteins.

DNA modulates structural transitions and oligomerization kinetics of the functional amyloid CRES

The paper shows DNA binding accelerates CRES amyloid formation by altering oligomerization pathways and kinetics, suggesting a regulatory mechanism for functional amyloid diversity.

Alternatively-Spliced CAMKK2 isoforms drive differential metabolic stress response and the regulation of ferroptosis

This study shows that CAMKK2 isoforms LF and SF have distinct roles in metabolic stress response and ferroptosis regulation in cancer cells.

A Point Mutation in the RNA Recognition Motif of CSTF2 Associated with Intellectual Disability in Humans Causes Defects in 3' End Processing