Author

Jiayin Hong

Harvard UniversityORCID 0000-0002-2212-558XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Organism:yeast· 2 Research Focus:benchmarking· 1 Assay:ChIP-seq· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Bo HuaiD· 2 shared Michael SpringeriD· 2 shared Ayşe Derya CavgaiD· 1 shared Chao TangiD· 1 shared Devina ShahiD· 1 shared Ernest D. LaueiD· 1 shared Julius PalmeiD· 1 shared Jussi TaipaleiD· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 11 mutual co-author links

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2 shared papersSystems Biology

Bo HuaORCID

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3 papers

Recent·Most cited

Scaling laws of human transcriptional activity

Jiayin Hong, Ayşe Derya Cavga, Devina Shah, Ernest D. Laue, Jussi Taipale

The paper investigates how chromosome size affects transcriptional activity and finds that gene expression scales with the surface-area-to-volume ratio, suggesting active genes are located at chromosomal surfaces.

bioRxiv · Aug 10, 2023 · PreprintGenetics

Computational analysis of GAL pathway pinpoints mechanisms underlying natural variation

Jiayin Hong, Julius Palme, Bo Hua, Michael Springer

The paper identifies key parameters in the GAL pathway that explain natural variation in yeast's response to galactose, using computational modeling and in silico perturbation.

PLoS Computational Biology · Sep 27, 2021Peer-reviewedSystems Biology

Computational study on ratio-sensing in yeast galactose utilization pathway

Jiayin Hong, Bo Hua, Michael Springer, Chao Tang

This study uses computational models to show that ratio-sensing in yeast galactose utilization arises from competition between carbon sources for transporters and transcription factors, and reveals design principles for synthetic biology applications.

PLoS Computational Biology · Dec 4, 2020Peer-reviewedSystems Biology