Devina Shah

Chromatin remodelling enables enhancer resetting to facilitate the ERK transcriptional response

The paper shows that chromatin remodelling by NuRD enables enhancer resetting in response to ERK signalling in mouse ES cells, facilitating a rapid and precise transcriptional response.

The chromatin remodeller CHD4 regulates transcription factor binding to both prevent activation of silent enhancers and maintain active regulatory elements

This study identifies CHD4's role in restricting transcription factor binding to maintain regulatory function and silence cryptic enhancers.

HP1β and densely packed chromatin form separate microdomains in mouse ES cells, which are reconfigured upon exit from naive pluripotency

Scaling laws of human transcriptional activity

The paper investigates how chromosome size affects transcriptional activity and finds that gene expression scales with the surface-area-to-volume ratio, suggesting active genes are located at chromosomal surfaces.