Ernest D. Laue

The paper shows that chromatin remodelling by NuRD enables enhancer resetting in response to ERK signalling in mouse ES cells, facilitating a rapid and precise transcriptional response.

This study identifies CHD4's role in restricting transcription factor binding to maintain regulatory function and silence cryptic enhancers.

The paper studies 3D genome structure changes in single mouse ES cells exiting pluripotency, finding reorganization of enhancer-promoter interactions through multiway chromatin hubs.

The paper investigates how chromosome size affects transcriptional activity and finds that gene expression scales with the surface-area-to-volume ratio, suggesting active genes are located at chromosomal surfaces.

The paper identifies novel imprinted genes in mouse blastocysts and shows that their expression is mostly independent of DNA methylation but associated with H3K27me3 marks.