Sensitive, highly multiplexed sequencing of microhaplotypes from the Plasmodium falciparum heterozygome
Sofonias Kifle Tessema, Nicholas J. Hathaway, Noam Teyssier, Maxwell Murphy, Anna Chen, Özkan Aydemir, Elias Michael Duarte, Wilson Simone, James M. Colborn, Francisco Saúte, Emily D. Crawford, Pedro Aíde, Jeffrey A. Bailey, Bryan Greenhouse
The paper develops a method to sequence microhaplotypes from Plasmodium falciparum heterozygomes, achieving high coverage, specificity, and sensitivity for detecting polyclonal infections.
The Journal of Infectious Diseases · Aug 24, 2020Peer-reviewedMolecular Biology