Nicholas J. Hathaway

The paper characterizes the population structure and drug resistance of Plasmodium falciparum in Uganda and neighboring countries using whole-genome data, identifying key resistance-associated haplotypes.

PfPHAST is a streamlined amplicon sequencing panel for malaria genomic surveillance, offering better quality control and cost efficiency than MAD4HatTeR without sacrificing performance on shared targets.

The paper introduces a standardized format for storing phased targeted sequencing data and provides tools to create and manipulate this format.

The paper develops MAD4HatTeR, an amplicon sequencing panel and analysis pipeline for detecting Plasmodium falciparum diversity, resistance markers, and gene duplications/deletions, showing high sensitivity and reproducibility across settings.

The paper analyzes whole-genome-sequenced Plasmodium falciparum samples to understand gene deletions associated with malaria rapid diagnostic tests, identifying patterns of chromosomal rearrangements and duplication.

Novel malaria SHERLOCK assays enabled robust detection, speciation, and genotyping of Plasmodium spp. in diverse samples collected in Africa and Asia.

The paper develops a method to sequence microhaplotypes from Plasmodium falciparum heterozygomes, achieving high coverage, specificity, and sensitivity for detecting polyclonal infections.

This study analyzes the genetic structure of Plasmodium falciparum in the DRC, identifying an east-west haplotype divide linked to antimalarial resistance and evidence of gene flow and selection pressures.