Noam Teyssier

This study identifies 772 genes regulating the interferon-responsive microglia state using CRISPRi screening in human iPSC-derived microglia, including novel regulators like CNOT10.

State, a set-based transformer trained on over 100 million perturbed cells, predicts perturbation responses in new cellular contexts better than mean, linear and deep learning baselines.

BINSEQ introduces binary formats for sequencing data to enable faster parallel processing, reducing analysis time for genome and transcriptome studies.

ProPer-seq is a cost-effective, barcode-free single-cell perturbation profiling method that enables scalable analysis of synthetic biology perturbations and reveals transcriptional control principles.

cyto processes 10x Genomics Flex single-cell sequencing data faster and more efficiently than existing tools, enabling large-scale single-cell genomics projects.

This study identifies mitochondrial respiration genes as critical for protein sensing and GLP-1 release in enteroendocrine cells through a CRISPR screen.

scBaseCount is a single-cell RNA sequencing database that automates metadata extraction and data processing using AI, offering a large, standardized collection of gene expression data across multiple organisms and tissues.

The paper introduces pyPAGE, an improved gene-set enrichment analysis tool, and applies it to uncover AD-associated regulons and their relationship to disease pathology.

The paper introduces multiAsCas12a, an engineered CRISPR-Cas12a variant enabling higher-order combinatorial chromatin perturbations, and demonstrates its use in discovering new enhancer elements and dissecting cis-regulatory element functions.

The paper develops a CRISPRi-based screening platform to identify genes affecting neuronal excitability in human iPSC-derived neurons, revealing new links to neurodegenerative and neurodevelopmental disorders.

The paper represses 87 high-confidence ASD genes in a human cortical neurogenesis model, identifying 17 genes that disrupt developmental trajectory and reveal convergence on microtubule biology and RNA-binding proteins.

This paper introduces GIA and BEDRS, tools that significantly improve the performance of genomic interval operations compared to existing tools.

The paper introduces CrAAVe-seq, an AAV-based CRISPR screening platform for in vivo cell type-specific analysis, demonstrating its scalability and sensitivity in identifying neuron-essential genes.

The paper identifies functional regulatory variants in GWAS loci for dementia, revealing cell-type specific transcriptional networks involved in disease risk.

This study optimizes whole-genome sequencing of Plasmodium falciparum from low-density dried blood spots by evaluating DNA extraction, digestion, and amplification methods.

The paper develops a method to sequence microhaplotypes from Plasmodium falciparum heterozygomes, achieving high coverage, specificity, and sensitivity for detecting polyclonal infections.