Shanika L. Amarasinghe

The paper identifies Gli1+ cells as fetal precursors of long-lived cartilage progenitors and shows they can compensate for cell-cycle arrest in cartilage.

This study shows that transient cartilage-specific cell death in fetal mouse limbs is repaired through a two-step process involving delayed and then accelerated chondroprogenitor differentiation, with mTORC1 activation playing a key role in recovery.

scPipe provides a preprocessing pipeline for single-cell ATAC-Seq and multi-modal data in R/Bioconductor, enabling quality control and downstream analysis.

The paper benchmarks long-read RNA-sequencing tools using synthetic data to evaluate isoform detection and differential expression analysis performance.

The paper develops FLT-seq and FLAMES to characterize full-length isoforms in single cells of human and mouse, identifying thousands of unannotated isoforms and linking them to functional modules and drug resistance mutations.