NOD2 modulates MDA5 signaling to promote coxsackievirus B3 replication
Sharon K. Kuss-Duerkop, Lauren C. Atencio, Elizabeth A. Nail, Ian L. Sparks, Thao Nguyen Thanh Huynh, Brian C. Russo, A. Marijke Keestra
This study shows that NOD2 promotes coxsackievirus B3 replication in intestinal epithelial cells by suppressing Type 1 Interferon expression and MDA5 activation through NOD2-mediated mitophagy.
bioRxiv · May 6, 2025 · PreprintImmunology