Thao Nguyen Thanh Huynh

This study shows that NOD2 promotes coxsackievirus B3 replication in intestinal epithelial cells by suppressing Type 1 Interferon expression and MDA5 activation through NOD2-mediated mitophagy.

This study shows that inhibiting ACAT1/SOAT1 in APOE4 mice reduces brain inflammation by lowering cholesterol esters and TLR4 levels.

This study evaluates a nanoparticle-formulated ACAT1 inhibitor in mice, showing brain delivery and reduced AD pathology without toxicity.

This study shows that blocking ACAT1 in microglia reduces LPS-induced neuroinflammation by altering TLR4 trafficking and degradation.