SARS-CoV-2 receptor ACE2 and TMPRSS2 are predominantly expressed in a transient secretory cell type in subsegmental bronchial branches
Soeren Lukassen, Robert Lorenz Chua, Timo B. Trefzer, Nicolas Carlos Kahn, Marc Andre Schneider, Thomas Muley, Hauke Winter, Michael A. Meister, Carmen Veith, Agnes W. Boots, Bianca P. Hennig, Michael Kreuter, Christian Conrad, Roland Eils
Single-cell profiling of lung and bronchial cells places ACE2 mainly in a transient secretory cell state of cultured bronchial epithelium, between goblet and ciliated cells, co-expressing TMPRSS2.
The EMBO Journal · Apr 14, 2020Peer-reviewedGenomics✦ In-depth digest