Soeren Lukassen

The paper investigates the role of Tbx1 in cardiopharyngeal mesoderm differentiation and morphogenesis, finding it stabilizes transcriptional profiles and regulates a conserved gene module.

This study shows that acute pancreatitis induces epigenetic changes in acinar cells, leading to long-term tumor predisposition through altered cell states and plasticity.

This study identifies ELF5 as a risk gene for severe COVID-19 using genetic and single-cell expression data, showing its specific expression in respiratory epithelial cells.

The paper introduces a hybrid model combining matrix factorization and variational autoencoders to infer gene sets from scRNA-seq data, correcting batch effects and identifying cell types.

The paper uses single nucleus and in situ RNA sequencing to create a comprehensive atlas of human pancreas cells, revealing cell topographies and differences between adult and neonatal pancreata.

The paper presents a drug-target-mechanism graph to identify synergistic drug combinations for SARS-CoV-2 treatment, validated through experimental testing.

Single-cell profiling of lung and bronchial cells places ACE2 mainly in a transient secretory cell state of cultured bronchial epithelium, between goblet and ciliated cells, co-expressing TMPRSS2.