Highly frequent undesired insertional mutagenesis during Drosophila genome editing
Emma Källstig, Evelyne Ruchti, Medha Raman, Jamshid Asadzadeh, Bernard Laurent Schneider, Brian D. McCabe
The paper identifies a frequent undesired insertional mutagenesis event during CRISPR/Cas9 HDR-based genome editing in Drosophila and proposes a solution to detect and exclude affected animals.
PLoS Genetics · Jul 9, 2026Peer-reviewedMolecular Biology