Brian D. McCabe

The paper identifies a frequent undesired insertional mutagenesis event during CRISPR/Cas9 HDR-based genome editing in Drosophila and proposes a solution to detect and exclude affected animals.

This study shows that spontaneous neurotransmitter release is regulated by the synaptic function of Unc-5 in Drosophila, affecting synaptic structure and behavior.

This paper shows that antimicrobial peptides damage neurons by binding to exposed phosphatidylserine, and that Turandot proteins protect neurons by reducing this interaction.

The paper develops new genetic tools for synchronous temporal control of transgenes in Drosophila tissues using hybrid binary gene regulatory systems.

This paper presents a synthetic biology and drone-based system to detect, degrade, and neutralize landmines safely and efficiently.

This study identifies FasII upregulation as a key factor in DM1 neuropathology using a Drosophila model, showing that manipulating FasII isoforms can rescue synaptic and behavioral defects.

This study identifies VGLUT-mediated mechanisms protecting DA neurons from PD-related degeneration, revealing sex-specific effects and transcriptional regulators.

The paper quantifies neurons and glia in the Drosophila larval CNS, revealing sexual dimorphism with more neurons in females and topological differences.

The paper identifies VGLUT expression as a sex-dependent mediator of age-related dopamine neuron vulnerability in Parkinson's disease.

This study shows miR-219 deficiency contributes to AD by dysregulating tau-kinase network through post-transcriptional mechanisms, leading to neurodegeneration and memory issues.