Cell BiologyeLifePeer-reviewed
Wnt induces FZD5/8 endocytosis and degradation and the involvement of RSPO-ZNRF3/RNF43 and DVL
Dong Luo, Jing Zheng, Shuning Lv…·Xinjun Zhang
This study shows Wnt induces FZD5/8 endocytosis and degradation via ZNRF3/RNF43, with RSPO1 stabilizing FZD5/8 and DVL promoting ligand-independent endocytosis.