Author

Huili Guo

Agency for Science, Technology and ResearchORCID 0000-0002-2294-5684Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Assay:Ribo-seq· 1

Frequent Co-Authors

Cheryl Siew Choo ChaniD· 1 shared Cui LiangiD· 1 shared Daniel YimiD· 1 shared Dasaradhi PalakodetiiD· 1 shared Deryn En-Jie TeohiD· 1 shared Iain BH Tan· 1 shared Indrik Wijaya· 1 shared IP Junyu· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperMolecular Biology

Cheryl Siew Choo ChanORCID

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2 papers

Recent·Most cited

ROS-induced translational regulation--through spatiotemporal differences in codon recognition--is a key driver of brown adipogenesis

Jun Yu Ip, Indrik Wijaya, Li Ting Lee, Yuhua Lim, Deryn En-Jie Teoh, Cheryl Siew Choo Chan, Cui Liang, Thomas J. Begley, Peter C. Dedon, Huili Guo

The paper shows that ROS-induced translational bias during brown adipogenesis supports mitochondrial biogenesis by preferentially translating G/C-ending codons through tRNA modification.

bioRxiv · Dec 22, 2023 · PreprintMolecular Biology

Dynamic expression of tRNA-derived small RNAs define cellular states

Daniel Yim, Srikar Krishna Gopinath, Vairavan Lakshmanan, Judice LY Koh, Jung Eun Park, Jit Kong Cheong, Joo-Leng Low, M.J. Lim, IP Junyu, Jie Min Nah, Iain BH Tan, Narayanan Gopalakrishna Iyer, Huili Guo, Siu Kwan Sze, Srikala Raghavan, , Ramanuj DasGupta

The paper identifies and functionally characterizes tRNA-derived small RNAs (tsRNAs) in cell state transitions, showing their role in regulating translation and stem cell states.

bioRxiv · Jul 1, 2017 · PreprintMolecular Biology