Siu Kwan Sze

Oxidative Stress-Induced Immunogenic Cell Death Enhances Whole-Cell Vaccine Efficacy in a Syngeneic Pancreatic Cancer Model

This study shows that inducing oxidative stress in pancreatic cancer cells creates an effective whole-cell vaccine that enhances anti-tumor immunity and synergizes with PD-1 blockade.

Bacterial suppression of intestinal fungi via activation of human gut γδ T-cells

The paper shows that bacterial metabolite HMB-PP activates human gut γδ T-cells to suppress fungal growth, but this mechanism is impaired in Crohn's disease.

IsoDGR-Induced Endothelial Cytoskeletal Disruption Drives Age-Related Blood-Brain Barrier Breakdown

This study identifies isoDGR-induced endothelial cytoskeletal disruption as a key driver of age-related BBB breakdown and shows that targeting isoDGR preserves BBB integrity and reduces neuroinflammation.

Anti-isoDGR Antibody Inhibits Atherosclerosis Induced by Western Diet in ApoE-/- mice

This study shows that an anti-isoDGR antibody reduces atherosclerosis and metabolic dysfunction in ApoE-/- mice fed a Western diet.

LOCAL REGULATION AND FUNCTION OF IMPORTIN-BETA 1 IN HIPPOCAMPAL NEURONS DURING TRANSCRIPTION-DEPENDENT PLASTICITY

This study shows importin-β1's role in nuclear import of soluble proteins during synaptic activity and long-term plasticity in hippocampal neurons.

Dynamics of murine brain protein synthesis in vivo identify the hippocampus, cortex and cerebellum as highly active metabolic sites

The paper uses pSILAC to identify brain regions with high protein synthesis activity and links them to metabolic and synaptic functions.

Dynamic expression of tRNA-derived small RNAs define cellular states

The paper identifies and functionally characterizes tRNA-derived small RNAs (tsRNAs) in cell state transitions, showing their role in regulating translation and stem cell states.