This study identifies WRKY transcription factors as mediators of NPR1-regulated SA/JA crosstalk in Arabidopsis, showing nuclear NPR1 controls JA repression through these factors.

Planta · Oct 28, 2026Peer-reviewedMolecular Biology

Root gene regulatory network analysis reveals roles for defense hormones and secondary metabolites in establishment of disease-suppressive soil

run Qi, Ivona Glavincheska, Jelle Spooren, Xiaoyan Liu, Marit Van Laatum, Francel W. A. Verstappen, Iris F. Kappers, Roeland L. Berendsen, Corne MJ Pieterse, Saskia C. M. Van Wees

The paper analyzes root gene regulatory networks in Arabidopsis thaliana to identify roles of defense hormones and secondary metabolites in disease-suppressive soil establishment.

bioRxiv · Oct 23, 2026 · PreprintPlant Biology

Modeling of Glucosinolate Biosynthesis During Biotic Stress as a Function of mRNA

Jordan Earle, Anna C. M. Neefjes, Xenja S.D. Ploeger, Marlene van Laar, Saskia C. M. Van Wees, Robert C. Schuurink, Aalt D. J. van Dijk, Petra Bleeker, Huub C. J. Hoefsloot

The paper models glucosinolate biosynthesis dynamics in Arabidopsis under biotic stress using a mechanistic ODE model constrained by gene expression and metabolite data.

bioRxiv · May 30, 2026 · PreprintSystems Biology

MEANtools: multi-omics integration towards metabolite anticipation and biosynthetic pathway prediction

Kumar Saurabh Singh, Hernando G. Suárez Duran, Elena Del Pup, Olga Zafra‐Delgado, Saskia C. M. Van Wees, Justin J. J. van der Hooft, Marnix H. Medema

MEANtools predicts metabolic pathways de novo by integrating transcriptomic and metabolomic data using reaction rules and enzyme families.

PLoS Biology · Jul 28, 2025Peer-reviewedBioinformatics