Author

Sudha B. Biddinger

Boston Children's HospitalORCID 0000-0002-2352-067XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1

Frequent Co-Authors

Arulsamy KulandaisamyiD· 1 shared Bandana SinghiD· 1 shared Beibei WangiD· 1 shared Bo ZhuiD· 1 shared Changcheng ZhouiD· 1 shared Chris A. BashuriD· 1 shared Da‐Zhi WangiD· 1 shared Douglas B. CowaniD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperCell Biology

Arulsamy KulandaisamyORCID

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2 papers

Recent·Most cited

PhysiologyMolecular MetabolismPeer-reviewedJul 16, 2025

The Diabetes Gene Tcf7l2 Organizes Gene Expression in the Liver and Regulates Amino Acid Metabolism

Joanna Krawczyk, William O’Connor, Pedro Henrique Vendramini…·Sudha B. Biddinger

This study shows Tcf7l2 maintains hepatic zonation and glutamine homeostasis, with loss of Tcf7l2 causing metabolic disruption and decreased glutamine levels.

3 citations

mousemetabolomics

Cell BiologybioRxivPreprintAug 26, 2024

Targeting Liver Epsins Ameliorates Dyslipidemia in Atherosclerosis through Inhibition of Proprotein Convertase Subtilisin/Kexin Type 9-Mediated Low-density Lipoprotein Receptor Degradation

Bo Zhu, Krishan Gupta, Kui Cui…·Hong Chen

This study shows that targeting liver epsins reduces atherosclerosis by preventing PCSK9-mediated LDLR degradation and improving LDL-C clearance.

4 citations

mousebulk RNA-seq