Author

Pedro Henrique Vendramini

Boston Children's HospitalORCID 0000-0001-9653-7248Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:metabolomics· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

Marcia C. HaigisiD· 2 shared Alcides Euzebio Tavares XavieriD· 1 shared Alessandro PreteiD· 1 shared Andris JankevicsiD· 1 shared Angela E. TayloriD· 1 shared Antoine TabariniD· 1 shared Betül Haykir· 1 shared Catherine L. WinderiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

Marcia C. HaigisORCID

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2 papers

Recent·Most cited

Glutamine antagonism suppresses tumor growth in adrenocortical carcinoma through inhibition of de novo nucleotide biosynthesis

Vasileios Chortis, Kleiton Silva Borges, Cong-Hui Yao, Claudio Henrique T. Ribeiro, Luís Fernando Peinado Nagano, Mesut Berber, Alessandro Prete, Lukáš Najdekr, Michail E. Klontzas, Andris Jankevics, Pedro Henrique Vendramini, Jean Lucas Kremer, Liam Kelley, Sathuwarman Raveenthiraraj, Alcides Euzebio Tavares Xavier, , David T. Breault

This study identifies glutamine antagonism as a therapeutic strategy for adrenocortical carcinoma by inhibiting de novo nucleotide biosynthesis and inducing DNA damage.

bioRxiv · Sep 28, 2025 · PreprintCancer Biology

The Diabetes Gene Tcf7l2 Organizes Gene Expression in the Liver and Regulates Amino Acid Metabolism

Joanna Krawczyk, William O’Connor, Pedro Henrique Vendramini, Mareike Schell, Kiran J. Biddinger, Matt Kanke, George Pengo, Ivana Semova, Tiffany Fougeray, Marcia C. Haigis, Krishna G. Aragam, Wouter H. Lamers, Linus T.-Y. Tsai, Praveen Sethupathy, Sudha B. Biddinger

This study shows Tcf7l2 maintains hepatic zonation and glutamine homeostasis, with loss of Tcf7l2 causing metabolic disruption and decreased glutamine levels.

Molecular Metabolism · Jul 16, 2025Peer-reviewedPhysiology