Abnormal neuronal and synaptic morphology in Down syndrome brains reproduces in human isogenic cellular models
Ante Plećaš, Gillian Gough, Danka Grčević, Hanna Jackowiak, Kinga Skieresz‐Szewczyk, Matija Horaček, Iva Šimunić, Željka Krsnik, Dinko Mitrečić, Aoife Murray, Dean Nižetić, Ivan Alić
This study shows that trisomy 21 in human isogenic iPSC-derived neurons leads to abnormal neuronal and synaptic morphology, similar to findings in human brain tissue.
Cell Death and Disease · Jun 10, 2026Peer-reviewedNeuroscience