Author

Gillian Gough

Nanyang Technological UniversityORCID 0000-0001-5837-0176Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:spatial domain detection· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Aoife MurrayiD· 2 shared Dean NižetićiD· 2 shared Dinko MitrečićiD· 2 shared Ivan AlićiD· 2 shared Željka KrsnikiD· 2 shared Agueda A. RostagnoiD· 1 shared André StrydomiD· 1 shared Anne Rovelet‐LecruxiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersNeuroscience

Aoife MurrayORCID

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2 papers

Recent·Most cited

NeuroscienceCell Death and DiseasePeer-reviewedJun 10, 2026

Abnormal neuronal and synaptic morphology in Down syndrome brains reproduces in human isogenic cellular models

Ante Plećaš, Gillian Gough, Danka Grčević…·Ivan Alić

This study shows that trisomy 21 in human isogenic iPSC-derived neurons leads to abnormal neuronal and synaptic morphology, similar to findings in human brain tissue.

1 citationtop 4%

humanspatial transcriptomics

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NeuroscienceMolecular PsychiatryPeer-reviewedJul 9, 2020

Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene-dose-sensitive AD-suppressor in human brain

Ivan Alić, Pollyanna Agnes Goh, Aoife Murray…·Henrik Zetterberg

The paper shows that trisomy 21 cerebral organoids exhibit AD-like pathology, which can be suppressed by BACE2 trisomy and inhibited by BACE1 inhibitors, suggesting BACE2 as an AD-suppressor gene.

123 citationstop 1%

humanproteomics

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