Yongjin J. Zhou

This paper engineers an energy-efficient pentose phosphate pathway in yeast to boost fatty acid production without compromising cell growth, achieving a record 41.7 g/L titer.

StrainOptimizer improves microbial cell factory design by integrating multi-scale metabolic models with expression and proteome constraints, achieving higher bioproduction in yeast.

This study characterizes the genomic and metabolic adaptations of Saccharomyces cerevisiae across diverse niches using pan-genome and metabolic modeling.