This study uses fMRI to compare counterconditioning and regular extinction in humans, finding distinct neural patterns and more persistent threat memory extinction with counterconditioning.

eLife · Feb 18, 2026Peer-reviewedNeuroscience

The Neural Blueprint of Stress Susceptibility: Brain-wide neuronal activity associated with the consequences of stress

Bart C.J. Dirven, Moritz Negwer, Andriana Botan, Riv Maas, Lennart V.J. van Melis, Sanne Merjenburgh, Rebecca van Rijn, Joanes Grandjean, Judith Regina Homberg, Tamás Kozicz, Marloes J. A. G. Henckens

This study identifies brain activity patterns associated with stress susceptibility in mice, highlighting key regions and network interactions linked to PTSD-like symptoms.

bioRxiv · Sep 27, 2024 · PreprintNeuroscience

Hippocampal trauma memory processing conveying susceptibility to traumatic stress

Bart C.J. Dirven, Lennart V.J. van Melis, Teya Daneva, Lieke Dillen, Judith Regina Homberg, Tamás Kozicz, Marloes J. A. G. Henckens

The paper investigates hippocampal memory processing differences in mice susceptible to PTSD-like symptoms following trauma exposure.

Neuroscience · Jan 12, 2024Peer-reviewedNeuroscience

StandardRat: A multi-center consensus protocol to enhance functional connectivity specificity in the rat brain

Joanes Grandjean, Gabriel Desrosiers-Grégoire, Cynthia Anckaerts, Diego Ángeles-Valdéz, Fadi Ayad, David André Barrière, Ines Blockx, Aleksandra B Bortel, Margaret Broadwater, Beatriz M Cardoso, Marina Célestine, Jorge E. Chavez-Negrete, Sangcheon Choi, Emma Christiaen, Perrin G Clavijo, , Kajo van der Marel

StandardRat improves functional connectivity specificity in rat brains through a standardized MRI protocol tested across 20 centers.

bioRxiv · Apr 27, 2022 · PreprintNeuroscience

Aberrant ventral dentate gyrus structure and function in individuals susceptible to post-traumatic stress disorder

Bart C.J. Dirven, Dewi van der Geugten, Miranda van Bodegom, Leonie Madder, Laura van Agen, Judith Regina Homberg, Tamás Kozicz, Marloes J. A. G. Henckens

The paper investigates structural and functional differences in the ventral dentate gyrus of mice susceptible to PTSD-like symptoms following trauma, identifying specific neuronal and synaptic changes associated with susceptibility.

bioRxiv · Oct 1, 2020 · PreprintNeuroscience