Moritz Negwer

The paper uses whole-brain clearing and imaging to identify region- and cell type-specific changes in GABAergic neurons in a mouse model of Kleefstra Syndrome.

This study identifies brain activity patterns associated with stress susceptibility in mice, highlighting key regions and network interactions linked to PTSD-like symptoms.

The paper identifies a novel pathway where astrocytes clear pre-synaptic autophagosomes from neurons through a cholesterol-dependent endocytosis process without requiring direct cell contact or retrograde transport.

This study compares the biodistribution of Fc-engineered molecules targeting BBB receptors with standard antibodies, showing distinct CNS and peripheral organ targeting.

DELiVR uses VR-generated data to train deep learning models for quantifying c-Fos in cleared mouse brains, revealing new activation patterns in cancer-related brain activity.

FriendlyClearMap simplifies and extends the ClearMap pipeline for mouse brain analysis, enabling efficient and scalable neuroanatomical studies.

The paper examines social interaction behaviors in Ehmt1+/- mice, finding they display defensive and offensive behaviors not seen in wild-type mice.

This study investigates the role of CDH13 in regulating GABAergic inhibition in human-derived neuronal networks and shows its impact on E/I balance.

This study shows that EHMT1 deficiency in human neurons leads to NMDAR hyperfunction, causing neuronal network dysfunction in Kleefstra syndrome, and demonstrates pharmacological rescue of these phenotypes.

The paper uses the Object Space Task to show Ehmt1 +/- mice have reduced episodic-like memory and exploration but enhanced semantic-like memory, with semantic features better for genotype classification.