Molecular BiologyMolecular Biology and EvolutionPeer-reviewed
Cell survival enabled by leakage of a labile metabolic intermediate
Encarnación Medina‐Carmona, Luis I. Gutierrez-Rus, Fadia Manssour-Triedo…·José M. Sánchez‐Ruiz
The paper shows that mutations in glutamine synthetase can rescue a proline biosynthesis block by leaking a phosphorylated intermediate, enabling a new pathway and organismal adaptation.