Cell survival enabled by leakage of a labile metabolic intermediate
Encarnación Medina‐Carmona, Luis I. Gutierrez-Rus, Fadia Manssour-Triedo, Matilda Newton, Gloria Gamiz-Arco, Antonio J. Mota, Pablo Reiné, Juan M. Cuerva, Mariano Ortega‐Muñoz, Eduardo Andrés‐León, Jose‐Luis Ortega Roldan, Burckhard Seelig, Beatriz Ibarra‐Molero, José M. Sánchez‐Ruiz
The paper shows that mutations in glutamine synthetase can rescue a proline biosynthesis block by leaking a phosphorylated intermediate, enabling a new pathway and organismal adaptation.
Molecular Biology and Evolution · Feb 9, 2023Peer-reviewedMolecular Biology