Gloria Gamiz-Arco

This study compares the substrate scope of a modern and ancestral family-1 glycosidase, finding the ancestral enzyme more efficient with large aglycon-containing flavonoid glycosides.

This paper shows DNAJC12 stabilizes activated PAH and reduces L-Phe needed for its activation, while also stabilizing a PKU-associated PAH variant.

The paper identifies heme protection by polypeptides as a mechanism enhancing catalytic efficiency in ancestral proteins, suggesting it may have driven the evolution of enzymes.

The paper shows that mutations in glutamine synthetase can rescue a proline biosynthesis block by leaking a phosphorylated intermediate, enabling a new pathway and organismal adaptation.