Eduardo Andrés‐León

Circular RNA-associated QTLs show stronger association with splicing-QTLs than with expression-QTLs

The paper compares circQTLs with splicing and expression QTLs, finding stronger genomic overlap with splicing-QTLs and distinct genomic distribution patterns.

Sex-biased Fibroblast Subpopulations and Transcriptional Programs Reveal Mechanisms of Skin Lesion Development in Systemic Sclerosis

The paper identifies sex-biased fibroblast subpopulations and transcriptional programs in systemic sclerosis, revealing sex-specific mechanisms of skin fibrosis.

Selective cross-TAD gene regulation by the Tcra enhancer during T cell development

The paper shows a Tcra enhancer can regulate a distal gene in a different TAD during T-cell development, challenging the idea that TAD boundaries block enhancer-promoter interactions.

A dual-function variant on chromosome 17 regulates circRNA expression and splicing in multiple sclerosis

The paper identifies genetic variants that regulate circRNA expression and splicing in multiple sclerosis, highlighting a dual-function variant on chromosome 17.

reanalyzerGSE: tackling the everlasting lack of reproducibility and reanalyses in transcriptomics

reanalyzerGSE provides a pipeline for reproducible and standardized reanalysis of transcriptomic data from local and public sources.

Cell survival enabled by leakage of a labile metabolic intermediate

The paper shows that mutations in glutamine synthetase can rescue a proline biosynthesis block by leaking a phosphorylated intermediate, enabling a new pathway and organismal adaptation.

Pluripotency factors regulate the onset of Hox cluster activation in the early embryo

This study shows pluripotency factors like OCT4 and NANOG initially repress and later enable activation of lineage specifiers, including the HoxB cluster, during early embryonic development.

RNA-seq, bioinformatic identification of potential MicroRNA-Like Small RNAs in the edible mushroom Agaricus bisporus and experimental approach for their validation

The paper identifies potential miRNA-like small RNAs in Agaricus bisporus using RNA-seq and validates them experimentally, suggesting possible interactions with human biological processes.